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1

Examining how context change foster service innovation

Edvardsson, Bo, Frow, Pennie, Jaakkola, Elina, Keiningham, Timothy Lee, Koskela-Huotari, Kaisa, Mele, Cristina, Tombs, Alastair

Journal:

Journal of Service Management

Year:

2018

Language:

english

File:

PDF, 261 KB

english, 2018

2

Umeclidinium/Vilanterol Versus Tiotropium/Olodaterol in Maintenance-Naïve Patients with Moderate Symptomatic Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis

Alcázar Navarrete, Bernardino, Boucot, Isabelle, Naya, Ian, Tombs, Lee, Lipson, David A., Compton, Chris, Sousa, Ana R., Feldman, Gregory

Journal:

Pulmonary Therapy

Year:

2018

Language:

english

File:

PDF, 457 KB

english, 2018

3

Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium

A.L. Des Tombe, B.J. Van Beek-Harmsen, M.B.E. Lee-De Groot, W.J. Van Der Laarse

Journal:

Microscopy Research and Technique

Year:

2002

Language:

english

File:

PDF, 2.76 MB

english, 2002

4

Sea urchin fertilization stimulates CaM kinase-II (multifunctional [type II] Ca2+/CaM kinase) activity and association with p34cdc2

Robert M. Tombes, Lee S. Peppers

Journal:

Development, Growth & Differentiation

Year:

1995

File:

PDF, 1.20 MB

1995

5

Including a time-of-year effect in the analysis of a matched case-control study

Nigel Stallard, Lee Tombs

Journal:

Statistics in Medicine

Year:

2004

Language:

english

File:

PDF, 132 KB

english, 2004

6

Authors' Reply

Nigel Stallard, Lee Tombs

Journal:

Statistics in Medicine

Year:

2005

Language:

english

File:

PDF, 28 KB

english, 2005

7

Laminin activates CaMK-II to stabilize nascent embryonic axons

Charles A. Easley, Milton O. Faison, Therese L. Kirsch, Jocelyn A. Lee, Matthew E. Seward, Robert M. Tombes

Journal:

Year:

2006

Language:

english

File:

PDF, 570 KB

english, 2006

8

Influence of Renal and Hepatic Impairment on the Pharmacokinetic and Pharmacodynamic Properties and Tolerability of Fluticasone Furoate and Vilanterol in Combination

Allen, Ann, Davis, Angela, Hardes, Kelly, Tombs, Lee, Kempsford, Rodger

Journal:

Clinical Therapeutics

Year:

2012

Language:

english

File:

PDF, 878 KB

english, 2012

9

The efficacy of once-daily fluticasone furoate/vilanterol in asthma is comparable with morning or evening dosing

Kempsford, Rodger D., Oliver, Amanda, Bal, Joanne, Tombs, Lee, Quinn, Dean

Journal:

Respiratory Medicine

Year:

2013

Language:

english

File:

PDF, 887 KB

english, 2013

10

Tolerability of Fluticasone Furoate/Vilanterol Combination Therapy in Children Aged 5 to 11 Years With Persistent Asthma

Oliver, Amanda, VanBuren, Sandi, Allen, Ann, Hamilton, Melanie, Tombs, Lee, Inamdar, Amir, Kempsford, Rodger

Journal:

Clinical Therapeutics

Year:

2014

Language:

english

File:

PDF, 472 KB

english, 2014

11

Effects of Moderate Hepatic Impairment on the Pharmacokinetic Properties and Tolerability of Umeclidinium and Vilanterol in Inhalational Umeclidinium Monotherapy and Umeclidinium/Vilanterol Combination Therapy: An Open-Label, Nonrandomized Study

Mehta, Rashmi, Hardes, Kelly, Kelleher, Dennis, Preece, Andrew, Tombs, Lee, Brealey, Noushin

Journal:

Clinical Therapeutics

Year:

2014

Language:

english

File:

PDF, 285 KB

english, 2014

12

A randomized, placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects

Kelleher, Dennis, Tombs, Lee, Preece, Andrew, Brealey, Noushin, Mehta, Rashmi

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 502 KB

english, 2014

13

The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of inhaled fluticasone furoate and vilanterol trifenatate in healthy subjects

Kempsford, Rodger, Allen, Ann, Bal, Joanne, Rubin, David, Tombs, Lee

Journal:

British Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 924 KB

english, 2013

14

Safety, tolerability, pharmacokinetics, and pharmacodynamics of vilanterol, a novel inhaled long-acting β-agonist, in children aged 5-11 years with persistent asthma: A randomized trial

Oliver, Amanda, VanBuren, Sandi, Allen, Ann, Hamilton, Melanie, Tombs, Lee, Kempsford, Rodger, Qaqundah, Paul

Journal:

Clinical Pharmacology in Drug Development

Year:

2014

Language:

english

File:

PDF, 257 KB

english, 2014

15

Safety, tolerability, pharmacokinetics, and pharmacodynamics of fluticasone furoate, a novel inhaled corticosteroid, in children aged 5-11 years with persistent asthma: A randomized trial

Oliver, Amanda, Allen, Ann, VanBuren, Sandi, Hamilton, Melanie, Tombs, Lee, Kempsford, Rodger, Qaqundah, Paul

Journal:

Clinical Pharmacology in Drug Development

Year:

2014

Language:

english

File:

PDF, 268 KB

english, 2014

16

Pacemaker-induced transient asynchrony suppresses heart failure progression

Kirk, J. A., Chakir, K., Lee, K. H., Karst, E., Holewinski, R. J., Pironti, G., Tunin, R. S., Pozios, I., Abraham, T. P., de Tombe, P., Rockman, H. A., Van Eyk, J. E., Craig, R., Farazi, T. G., Kass,

Journal:

Science Translational Medicine

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

17

Size Principle of Striated Muscle Cells

Van Der Laarse, W.J., Diegenbach, P.C., LEE-DE GROOT, M.B.E., Des Tombe, A.L.

Journal:

Netherlands Journal of Zoology

Year:

1997

Language:

english

File:

PDF, 1.34 MB

english, 1997

18

Triple Therapy of Umeclidinium + Inhaled Corticosteroids/Long-Acting Beta2 Agonists for Patients with COPD: Pooled Results of Randomized Placebo-Controlled Trials

Siler, Thomas M., Kerwin, Edward, Tombs, Lee, Fahy, William A., Naya, Ian

Journal:

Pulmonary Therapy

Year:

2016

Language:

english

File:

PDF, 698 KB

english, 2016

19

Utility of concentration-effect modeling and simulation in a thorough QT study of losmapimod

Barbour, April M., Magee, Mindy, Shaddinger, Bonnie, Arya, Niki, Tombs, Lee, Tao, Wenli, Patel, Bela R., Fossler, Michael J., Glaser, Ruchira

Journal:

Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 508 KB

english, 2015

20

Assessing Short-term Deterioration in Maintenance-naïve Patients with COPD Receiving Umeclidinium/Vilanterol and Tiotropium: A Pooled Analysis of Three Randomized Trials

Maleki-Yazdi, M. Reza, Singh, Dave, Anzueto, Antonio, Tombs, Lee, Fahy, William A., Naya, Ian

Journal:

Advances in Therapy

Year:

2016

Language:

english

File:

PDF, 700 KB

english, 2016

21

Semaphorin 3 C drives epithelial-to-mesenchymal transition, invasiveness, and stem-like characteristics in prostate cells

Tam, Kevin J., Hui, Daniel H. F., Lee, Wilson W., Dong, Mingshu, Tombe, Tabitha, Jiao, Ivy Z. F., Khosravi, Shahram, Takeuchi, Ario, Peacock, James W., Ivanova, Larissa, Moskalev, Igor, Gleave, Martin

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.94 MB

english, 2017

22

Comparative Efficacy of Once-Daily Umeclidinium/Vilanterol and Tiotropium/Olodaterol Therapy in Symptomatic Chronic Obstructive Pulmonary Disease: A Randomized Study

Feldman, Gregory J., Sousa, Ana R., Lipson, David A., Tombs, Lee, Barnes, Neil, Riley, John H., Patel, Sadhana, Naya, Ian, Compton, Chris, Alcázar Navarrete, Bernardino

Journal:

Advances in Therapy

Year:

2017

Language:

english

File:

PDF, 906 KB

english, 2017

23

Exploring the Comparative Efficacy and Safety of Once-Daily Umeclidinium/Vilanterol and Tiotropium/Olodaterol in Moderate Symptomatic COPD: A Randomized Non-Inferiority Crossover Trial

Feldman, Gregory, Sousa, Ana, Lipson, David, Tombs, Lee, Compton, Chris, Alcázar Navarrete, Bernardino

Journal:

Year:

2017

Language:

english

File:

PDF, 74 KB

english, 2017

24

Effects of umeclidinium/vilanterol on exercise endurance in COPD: a randomised study

Riley, John H., Kalberg, Chris J., Donald, Alison, Lipson, David A., Shoaib, Muhammad, Tombs, Lee

Journal:

ERJ Open Research

Year:

2018

Language:

english

File:

PDF, 451 KB

english, 2018

25

SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1

Peacock, James W, Takeuchi, Ario, Hayashi, Norihiro, Liu, Liangliang, Tam, Kevin J, Al Nakouzi, Nader, Khazamipour, Nastaran, Tombe, Tabitha, Dejima, Takashi, Lee, Kevin CK, Shiota, Masaki, Thaper, Da

Journal:

EMBO Molecular Medicine

Year:

2018

Language:

english

File:

PDF, 4.74 MB

english, 2018

26

Calcium signals act through histone deacetylase to mediate pronephric kidney morphogenesis

Rothschild, Sarah C., Lee, Hunter J., Ingram, Sarah R., Mohammadi, Daniel K., Walsh, Gregory S., Tombes, Robert M.

Journal:

Developmental Dynamics

Year:

2018

Language:

english

File:

PDF, 1.07 MB

english, 2018

27

Efficacy of Umeclidinium/Vilanterol in Elderly Patients with COPD: A Pooled Analysis of Randomized Controlled Trials

Ray, Riju, Tombs, Lee, Asmus, Michael J., Boucot, Isabelle, Lipson, David A., Compton, Chris, Naya, Ian

Journal:

Year:

2018

Language:

english

File:

PDF, 609 KB

english, 2018

28

Prevention of clinically important deteriorations in COPD with umeclidinium/vilanterol

Singh, Dave, Maleki-Yazdi, M. Reza, Tombs, Lee, Iqbal, Ahmar, Fahy, William A, Naya, Ian

Journal:

International Journal of Chronic Obstructive Pulmonary Disease

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

29

Relationship between exercise endurance and static hyperinflation in a post hoc analysis of two clinical trials in patients with COPD

Singh, Sally, Maltais, François, Tombs, Lee, Fahy, William A, Vahdati-Bolouri, Mitra, Locantore, Nicholas, Riley, John H

Journal:

International Journal of Chronic Obstructive Pulmonary Disease

Year:

2018

Language:

english

File:

PDF, 3.05 MB

english, 2018

30

Preventing Clinically Important Deterioration of COPD with Addition of Umeclidinium to Inhaled Corticosteroid/Long-Acting β2-Agonist Therapy: An Integrated Post Hoc Analysis

Naya, Ian P., Tombs, Lee, Lipson, David A., Compton, Chris

Journal:

Advances in Therapy

Year:

2018

Language:

english

File:

PDF, 1.01 MB

english, 2018

31

Effect of severe renal impairment on umeclidinium and umeclidinium/vilanterol pharmacokinetics and safety: a single-blind, nonrandomized study

Mehta, Rashmi, Hardes, Kelly, Brealey, Noushin, Tombs, Lee, Preece, Andrew, Kelleher, Dennis

Journal:

International Journal of Chronic Obstructive Pulmonary Disease

Year:

2014

Language:

english

File:

PDF, 427 KB

english, 2014

32

Long-term outcomes following first short-term clinically important deterioration in COPD

Naya, Ian P., Tombs, Lee, Muellerova, Hana, Compton, Christopher, Jones, Paul W.

Journal:

Respiratory Research

Year:

2018

Language:

english

File:

PDF, 950 KB

english, 2018

33

EFFECT OF AGE ON EFFICACY AND SAFETY OF ONCE-DAILY UMECLIDINIUM IN PATIENTS WITH COPD

SOULE, TEDI, CAVENEY, SCOTT, TOMBS, LEE, NAYA, IAN, BOUCOT, ISABELLE

Journal:

Year:

2018

File:

PDF, 92 KB

2018

34

Impact of prior and concurrent medication on exacerbation risk with long-acting bronchodilators in chronic obstructive pulmonary disease: a post hoc analysis

Naya, Ian, Tombs, Lee, Lipson, David A., Boucot, Isabelle, Compton, Chris

Journal:

Respiratory Research

Year:

2019

Language:

english

File:

PDF, 998 KB

english, 2019

35

Efficacy and safety of the dual bronchodilator combination umeclidinium/vilanterol in COPD by age and airflow limitation severity: A pooled post hoc analysis of seven clinical trials

Ray, Riju, Tombs, Lee, Naya, Ian, Compton, Chris, Lipson, David A., Boucot, Isabelle

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2019

Language:

english

File:

PDF, 912 KB

english, 2019

36

Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised trial

Maltais, François, Bjermer, Leif, Kerwin, Edward M., Jones, Paul W., Watkins, Michael L., Tombs, Lee, Naya, Ian P., Boucot, Isabelle H., Lipson, David A., Compton, Chris, Vahdati-Bolouri, Mitra, Vogel

Journal:

Respiratory Research

Year:

2019

Language:

english

File:

PDF, 1.61 MB

english, 2019

37

Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised trial

Maltais, François, Bjermer, Leif, Kerwin, Edward M., Jones, Paul W., Watkins, Michael L., Tombs, Lee, Naya, Ian P., Boucot, Isabelle H., Lipson, David A., Compton, Chris, Vahdati-Bolouri, Mitra, Vogel

Journal:

Respiratory Research

Year:

2019

File:

PDF, 1.61 MB

2019

38

Phase I Study of Sorafenib and Vorinostat in Advanced Hepatocellular Carcinoma

Gordon, Sarah W., McGuire, William P., Shafer, Danielle A., Sterling, Richard K., Lee, Hannah M., Matherly, Scott C., Roberts, John D., Bose, Prithviraj, Tombes, Mary B., Shrader, E. Ellen, Ryan, Alis

Journal:

American Journal of Clinical Oncology

Year:

2019

File:

PDF, 148 KB

2019

39

Early and sustained symptom improvement with umeclidinium/vilanterol versus monotherapy in COPD: a post hoc analysis of the EMAX randomised controlled trial

Kerwin, Edward M, Boucot, Isabelle H, Vogelmeier, Claus F, Maltais, Francois, Naya, Ian P, Tombs, Lee, Jones, Paul W, Lipson, David A, Keeley, Tom, Bjermer, Leif

Journal:

Therapeutic Advances in Respiratory Disease

Year:

2020

File:

PDF, 444 KB

2020

40

Measuring disease activity in COPD: is clinically important deterioration the answer?

Singh, Dave, Criner, Gerard J., Naya, Ian, Jones, Paul W., Tombs, Lee, Lipson, David A., Han, MeiLan K.

Journal:

Respiratory Research

Year:

2020

File:

PDF, 1.30 MB

2020

41

Impact of baseline COPD symptom severity on the benefit from dual versus mono-bronchodilators: an analysis of the EMAX randomised controlled trial

Vogelmeier, Claus F., Kerwin, Edward M., Bjermer, Leif H., Tombs, Lee, Jones, Paul W., Boucot, Isabelle H., Naya, Ian P., Lipson, David A., Compton, Chris, Barnes, Neil, Maltais, FranÃ§ois

Journal:

Therapeutic Advances in Respiratory Disease

Year:

2020

File:

PDF, 536 KB

2020